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The secret to healthy and glowing skin.

Back to basics

In skincare, the most powerful innovations are often the ones that bring us back to the basics—specifically, back to our skin’s own biology.

Skin-identical ingredients are compounds naturally present in healthy human skin. These include essential lipids like ceramides, cholesterol, fatty acids, and squalane, as well as components of the Natural Moisturizing Factor (NMF)—such as urea, amino acids, sodium PCA, hyaluronic acid, and lactic acid.

These ingredients aren’t just compatible—they’re familiar. Your skin already knows how to use them.

Biocompatible & Safe

What Makes Skin-Identical Ingredients So Effective?  Because these ingredients are structurally and functionally the same as what exists in your skin, they offer:

  • High biocompatibility – They integrate seamlessly into your skin’s barrier and cell matrix making them the safest ingredients available.
  • Proven hydration – They attract and retain moisture in the exact way your skin is designed to.
  • Barrier repair – They reinforce the lipid matrix that protects against environmental stress and water loss.
  • Microbiome support – By preserving your skin’s natural pH and moisture balance, they foster a healthy ecosystem of good bacteria.

In short, skin-identical ingredients don’t overwhelm your skin—they restore it.

Clinically Proven

Numerous clinical studies confirm the effectiveness of skin-identical ingredients in improving skin health and delaying signs of aging.

💧 Hydration

    • Glycerin & Hyaluronic Acid: A 2021 study by Dr. Zoe Draelos found that a formula containing glycerin and hyaluronic acid increased skin hydration by over 40% within two weeks, even for sensitive skin types.

    • Urea: Research from Lodén (2005) showed that urea not only significantly increased moisture retention but also strengthened the skin barrier, especially in dry or atopic skin.

    • Sodium PCA: A 2020 study by Egawa et al. found sodium PCA outperformed glycerin in water-binding capacity, making it a powerful humectant for long-lasting hydration.

🛡️ Barrier Repair

  • Ceramides: A 2018 review by Draelos concluded that ceramide-rich moisturizers were significantly more effective than petroleum-based products at restoring the skin barrier, particularly in conditions like eczema and rosacea.

  • Squalane (Neossance Study): In a clinical trial with 30 participants, using Neossance Squalane twice daily for 28 days led to a ~18% reduction in transepidermal water loss (TEWL) and a measurable improvement in the skin’s lipid barrier function.

🌞 Protection & Regeneration

  • Squalane: In laboratory studies on human dermal fibroblasts exposed to UVA radiation, squalane helped protect against collagen breakdown and oxidative stress, and promoted wound healing, indicating potent antioxidant and regenerative properties.

These are just a few examples among many. A growing body of dermatological research continues to validate the remarkable efficacy of skin-identical ingredients in supporting healthy, resilient, and youthful skin.

Microbiome-Safe

Unlike harsh actives or synthetic fillers, skin-identical ingredients respect your skin’s pH and structure. This naturally supports your microbiome—the invisible army of good bacteria that strengthens your immunity, calms inflammation, and prevents breakouts.

One standout is lactic acid, naturally produced by your own skin bacteria. It helps maintain the skin’s ideal slightly acidic pH, creating an environment where your microbiome can thrive—while also gently exfoliating, hydrating, and encouraging skin renewal to prevent buildup and clogged pores.

Twin Skin formulations are carefully pH-optimized by lactic acid itself to match the skin’s physiological pH, ensuring maximum compatibility and microbiome balance without disruption.

When your barrier is intact and hydrated, and your microbiome is thriving, your skin becomes more resilient, radiant, and self-sufficient.

Skin Identical Beauty

Twin Skin is a pioneer in premium skincare because it doesn’t just promise results—it works in sync with your skin biology to deliver them. At the heart of every Twin Skin formula are high concentrations of skin-identical ingredients, including:

  • Essential lipids: ceramides, omega fatty acids, squalane
  • NMF components: glycerin, sodium PCA, urea, hyaluronic acid, amino acids, lactic acid
  • Advanced biomimetic actives: peptides and barrier-strengthening molecules

These ingredients don’t just moisturize—they restore skin intelligence. They train your skin to repair itself, rebalance its microbiome, and stay hydrated and protected without constant correction.

IntelligentNot Aggressive

We’ve spent years chasing instant results with harsh actives, aggressive peels, and synthetic ingredients. But real skin health comes from restoring what your skin is already designed to do.

Skin-identical ingredients offer a proven, science-backed way to care for your skin—gently, effectively, and intelligently.

Twin Skin is leading this evolution, redefining what it means to be truly premium skincare:

🌿 Rooted in science.

🧬 Grounded in human biology.

✨ Designed to restore—not override—your skin.

Are you ready to listen to your skin speak?

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